A 1-year longitudinal study on COVID-19 convalescents reveals persistence of anti-SARS-CoV-2 humoral and cellular immunityCOVID-19 회복기에 대한 1년 종단 연구는 항 SARS-CoV-2 체액성 및 세포성 면역의 지속성을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 1-year after infection anti-SARS-CoV-2 humoral antibody antibody durability. caused CD4 CD8 CD8 T cell CD8 T cell responses Cell cellular immunity central memory circulating antibodies circulating antibody Cohort convalescent COVID-19 COVID-19 convalescent COVID-19 patient disease disease severity effective IgG level immune Immune components immune memory immune protection Immunity induce Infection information Kinetics maintain memory memory B memory B cell Memory responses memory T cells omicron Omicron variant peptide peptide pool persistence protective immunity provide RBD IgG Re-infection recorded response reveal SARS-CoV-2 SARS-CoV-2 circulating antibodies SARS-COV-2 infection subject Symptom T cell T cell response T cell responses T cells tested the RBD the SARS-CoV-2 variant [DOI] 10.1080/22221751.2022.2049984 PMC 바로가기 [Article Type] Article
Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversionArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addition antibodies Antibody Response approach AUC collected COVID-19 COVID-19 patient diagnostic diagnostics Donor Extreme early-stage seroconversion faster flow cytometry healthy IgG IgG and IgM IgG/IgM antibodies IgM immunoassay immunoassays immunological inactivated nucleic acid nucleic acids other diseases pathogen-specific Patient peptide platform probe Protein RBD reveal Rhesus monkeys SARS-CoV-2 S2 sensitivity Seroconversion seroconversion time Simoa tested Ultrasensitive digital detection. vaccination virus wild-type [DOI] 10.1016/j.bios.2022.114710 PMC 바로가기
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Perception and determinants of Social Networking Sites (SNS) on spreading awareness and panic during the COVID-19 pandemic in BangladeshResearch article Published on 2022-12-012022-10-05 Journal: Health Policy OPEN [Category] 치료기술, [키워드] assist Awareness Bangladesh Chi-square collected COVID-19 COVID-19 pandemic determinant determine Facebook form Google highest information Logistic regression Logistic regression analysis media medium misinformation multivariate networking pandemic Panic participant Pearson Perception performed Prevent regulate Research Result reveal significantly Site social media Social networking site Spread survival unique variable variables [DOI] 10.1016/j.hpopen.2022.100075 [Article Type] Research article
Whole-genome sequence analysis reveals the circulation of multiple SARS-CoV-2 variants of concern in Nairobi and neighboring counties, Kenya between March and July 2021Article Published on 2022-11-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] adaptive analysis analyzed B.1.1.7 B.1.351 B.1.617.2 Beta bioinformatics circulation community transmission comparison Coronaviruses COVID-19 COVID-19 cases Delta Epidemics genome sequence increase in Kenya Lineage majority Mutation Neutralizing antibodies Oxford Nanopore Technologies Phylogenetic Prevalence protocol reduced Region regions reveal RNA RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2. sequence Sequence analysis Sequencing Spread Strains study period the SARS-CoV-2 variant virulence virus virus transmissibility VoC was performed [DOI] 10.1186/s12985-022-01895-y PMC 바로가기
Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
The pH Robustness of Bacterial SensingArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] 유전자 메커니즘, [키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction signal transduction. Signaling TAR tested ultracentrifugation was obtained [DOI] 10.1128/mbio.01650-22 PMC 바로가기
Direct modelling from GPS data reveals daily-activity-dependency of effective reproduction number in COVID-19 pandemicArticle Published on 2022-10-252022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] activities activity calculated COVID-19 pandemic defined delta variant Direct Effect effective Government Infection infection rate infection risk Measures Quantitative Reproduction number reveal social contact Spread suppressed Tokyo vaccination [DOI] 10.1038/s41598-022-22420-9 PMC 바로가기